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No. 9, Rua de Latitude, Distrito de Xixia, Nanjing
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Nanjing Kobei Biotecnologia Co., Ltd.
RXFP2 K658E CHO
NegociávelAtualização em05/06
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RXFP2 [K658E] CHO
Detalhes do produto
RXFP2 [K658E] CHO
| I. Background | |
| RXFP（Relaxin Family Peptide Receptor）家族是一类 G 蛋白偶联受体，包含 RXFP1、 RXFP2、RXFP3 和 RXFP4 四个成员。RXFP2，又称为 LGR8、GREAT，其蛋白质结构具有七次跨膜结构域、胞外富重复序列以及一个低密度脂蛋白 A 类模块，主要生理性配体为胰岛素样肽 3（INSL3）。 在胎儿期，INSL3 与 RXFP2 结合活化下游信号通路（如增加细胞内 cAMP 水平），驱 动睾丸的经腹下降过程；功能失效会导致双侧隐睾。进入青春期后，RXFP2 表达水平随睾酮升高而提升，并直接参与精子发生与成熟，尤其在圆形精子细胞向成熟精子分化阶段。该受体功能受损可造成生精停滞和非梗阻性无精子症。此外，RXFP2 还可能参与免疫调节和骨代谢等生理过程。 | |
| II. Description | |
RXFP2[K658E] CHO细胞药靶模型很好的模拟了体内RXFP2[K658E]的信号转导过程， 原理见下图所示。 Figure 1. RXFP2[K658E] CHO 细胞模型原理图 | |
| III. Introduction | |
| Expressed gene: | RXFP2 [K658E] |
| Host Cell: | CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): | Functional assay for RXFP2 [K658E] Receptor |
| Assay Format: | Gs |
| IV. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| V. Representative Data
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